Chromosome aberrations in B lymphocytes of atomic bomb survivors
نویسندگان
چکیده
منابع مشابه
Comparison of Conventional Staining Method versus FISH to detect Stable-type Chromosome Aberrations in Lymphocytes from Atomic-bomb Survivors
INTRODUCTION Chromosome aberration frequency in peripheral blood lymphocytes has long been used as a quantitative biomarker for radiation dose assessment. Unstable-type aberrations represented by dicentrics and rings are reliably scored by conventional staining method because of unusual shapes of chromosomes, and the frequency is recommended for the purpose of biological dosimetry (1, 2). Unfor...
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As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micro...
متن کاملChromosome Aberrations in B Lymphocytes
Although chromosome aberrations in T lymphocytes and bone marrow cells have been reported in atomic bomb survivors, the presence of chromosome abnormalities has not been demonstrated in B lymphocytes because of the technical difficulties involved in B-lymphocyte separation. A method for detecting chromosome aberrations in B lymphocytes was established by “stimulation” of B lymphocytes with Epst...
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One hundred enamel samples isolated from extracted teeth donated by atomic bomb survivors were subjected to free radical measurement by means of electron paramagnetic resonance (ESR). Results comparing ESR with the chromosome aberration frequency in lymphocytes of the tooth donors, and with the physically estimated DS86 dose suggested that ESR data correlated more closely with chromosome data t...
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Radiation has been associated with increases in noncancerous diseases. An effect of low-dose radiation on the prevalence of clinically detected glaucoma has not been previously reported. We therefore investigated the prevalence of glaucoma in A-bomb survivors and its possible association with radiation dose. A total of 1,589 people who participated in the clinical examination program for A-bomb...
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ژورنال
عنوان ژورنال: Blood
سال: 1979
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v53.6.1140.bloodjournal5361140